The place of tachykinin NK2 receptor antagonists in the treatment diarrhea-predominant irritable bowel syndrome
A Szymaszkiewicz, A Malkiewicz… - … of Physiology and …, 2019 - publicum.umed.lodz.pl
… two selective NK2 receptor antagonists: nepadutant (MEN11420) and ibodutant (MEN15596) …
This novel non-peptide molecule was designed for the treatment of IBS-D by Menarini (57-…
This novel non-peptide molecule was designed for the treatment of IBS-D by Menarini (57-…
Tachykinin NK2 antagonist for treatments of various disease states
… A novel selective nonpeptide NK 2 antagonist, saredutant [… Currently, no selective NK 2
receptor antagonists have been … ibodutant [MEN 15596] are NK 2 receptor antagonists that are …
receptor antagonists have been … ibodutant [MEN 15596] are NK 2 receptor antagonists that are …
Gender-related differences of tachykinin NK2 receptor expression and activity in human colonic smooth muscle
S Drimousis, I Markus, TV Murphy, DS Perera… - … of Pharmacology and …, 2020 - ASPET
… In patients with diarrhea-predominant irritable bowel syndrome, the NK 2 receptor antagonist
ibodutant had a greater therapeutic effect in females than males. The present study aimed …
ibodutant had a greater therapeutic effect in females than males. The present study aimed …
[HTML][HTML] Harnessing the Anti-Nociceptive Potential of NK2 and NK3 Ligands in the Design of New Multifunctional μ/δ-Opioid Agonist–Neurokinin Antagonist …
C Gadais, J Piekielna-Ciesielska, J De Neve, C Martin… - Molecules, 2021 - mdpi.com
… -peptidic, and non-peptide neurokinin NK2 and NK3 ligands were … In the first generation of
patented NK2 receptor antagonists, … , MEN 15,596 or Ibodutant stood out as a NK2 antagonist …
patented NK2 receptor antagonists, … , MEN 15,596 or Ibodutant stood out as a NK2 antagonist …
The neurokinins: peptidomimetic ligand design and therapeutic applications
C Gadais, S Ballet - Current Medicinal Chemistry, 2020 - ingentaconnect.com
… resemblance with known rigid non-peptide antagonists [145]. … Tachykinin NK2 receptors are
widely distributed in … tion [163], from which, MEN 15596 or Ibodutant 106, the best analogue, …
widely distributed in … tion [163], from which, MEN 15596 or Ibodutant 106, the best analogue, …
Tachykinin receptors in GtoPdb v. 2023.1
J Barrett, B Canning, J Coulson… - IUPHAR/BPS Guide …, 2023 - journals.ed.ac.uk
… (1994) The nonpeptide tachykinin NK2 receptor antagonist SR 48968 interacts with
human, … (2006) MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist. Eur J …
human, … (2006) MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist. Eur J …